
Application of Ion Exchange Resin in Drug Extraction
Ion
exchange resins are widely used in drug extraction. The refining and
purification of drugs is to convert the effective components in the drug solution
into ionic form, exchange with the resin, adsorb the effective components,
convert the effective components into salt using the principle of acid-base
salt formation, and then elute, elute the low concentration effective
components in the drug extract after being adsorbed by the ion exchange resin,
improve the content of the effective components, and achieve the goal of drug
refining and purification. Its application mainly focuses on antibiotics, such
as the extraction, decolorization, refining and desalination of streptomycin,
the extraction and decolorization of gentamicin, the extraction and
decolorization of neomycin sulfate, the extraction of kanamycin, the
decolorization of oxytetracycline, the extraction and desalination of colistin
sulfate. These processes all use a large number of ion exchange resins.
Weak
acid cation exchange resin is mainly used for drug extraction, strong base
anion exchange resin is mainly used for drug decolorization, and high
crosslinking strong acid cation exchange resin is used for drug desalination.
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